Studies on the Pathophysiology of Sickle Cell Disease

Article1 February 1945STUDIES ON THE PATHOPHYSIOLOGY OF SICKLE CELL DISEASEROBERT C. LOWE, M.D., F.A.C.P., C. C. ADAMSROBERT C. LOWE, M.D., F.A.C.P.Search for more papers by this author, C. C. ADAMSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-2-192 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subject of sickle cell disease has been rather extensively studied with respect to its clinical1, 2, 3and pathological4, 5, 6aspects. Some work7, 8, 9has been done to study the disease in a dynamic physiologic way, especially with reference to the hemolytic mechanisms and the peculiar pathophysiology of the red blood cells so characteristic of this disease. Inferences are drawn from these studies to explain the terminal histology as well as many of the clinical aspects. Our interest has been centered on fairly long term studies of the pigment metabolism as one of the dynamic mechanisms which...Bibliography1. WINTROBE MW: Clinical hematology, 1942, Lea and Febiger, Philadelphia. CrossrefGoogle Scholar2. BAUER J: Sickle cell disease, Arch. Surg., 1940, xli, 1344-1362. CrossrefGoogle Scholar3. JOHNSONTOWNSEND FBEW: Sickle cell anemia, South. Med. and Surg., 1937, xcix, 377-381. Google Scholar4. DIGGSCHING LWRE: Pathology of sickle cell anemia, South. Med. Jr., 1934, xxvii, 839-845. CrossrefGoogle Scholar5. DIGGS LW: Siderofibrosis of the spleen in sickle cell anemia, Jr. Am. Med. Assoc., 1935, civ, 538-541. CrossrefGoogle Scholar6. STASNEY J: Erythrophagocytosis and hemosiderosis in the liver and spleen in sickle cell disease, Am. Jr. Path., 1943, xix, 225-237. Google Scholar7. JOSEPHS HW: Studies in hemolytic anemia, Bull. Johns Hopkins Hosp., 1938, lxii, 53-69, 70-76. Google Scholar8. HAHNGILLESPIE EVEB: Sickle cell anemia, Arch. Int. Med., 1927, xxxviv, 232-254. Google Scholar9. WINDSORBURCH TGE: The rate of sedimentation of erythrocytes in sickle cell anemia, Arch. Int. Med., 1944, lxxiii, 41-52. CrossrefGoogle Scholar10. KLINEFELTER HF: The heart in sickle cell anemia, Am. Jr. Med. Sci., 1942, cciii, 34-51. CrossrefGoogle Scholar11. LOWE RC: A study of hemoglobin metabolism and hematology in a case of congenital hemolytic jaundice, Am. Jr. Med. Sci., 1943, ccvi, 347-352. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana*Received for publication May 9, 1944.From the Department of Medicine, Louisiana State University School of Medicine, and the Charity Hospital of Louisiana at New Orleans. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWedged Hepatic Venous Pressure in Congenital Heart DiseaseSickle Cell Disease and Viral HepatitisELIZABETH BARRETT-CONNOR, M.D. 1 February 1945Volume 22, Issue 2Page: 192-200KeywordsHistologyHospital medicineRed blood cellsSickle cell disease ePublished: 1 December 2008 Issue Published: 1 February 1945 PDF downloadLoading ...