Since the discovery and sequencing of 6-deoxyerythronolide B synthase 20 years ago, this exceptionally large, multifunctional protein remains the paradigm for the understanding of the structure and biochemical function of modular polyketide synthases. The broad-spectrum macrolide antibiotic erythromycin is one of several hundred closely related, branched chain, polyoxygenated polyketides, many of which are widely used in human and veterinary medicine as antibiotic, immunosuppressant, antitumor, antifungal, and antiparasitic agents.
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David E. Cane (2010) studied this question.
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