Why the study?
Does the combination of bisphosphonates and statins improve aortic stiffness and blood pressure in postmenopausal women with osteoporosis?
Does the combination of bisphosphonates and statins improve aortic stiffness and blood pressure in postmenopausal women with osteoporosis?
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Combining statins with bisphosphonates in postmenopausal women with osteoporosis may provide dual benefits by improving both bone mineral density and parameters of arterial stiffness and blood pressure.
The study shows that addition of statins to osteoporotic therapy in postmenopausal women with different cardiovascular risk beside desired hypolipidemic effect and reduction of arterial stiffness also elevates BMD at femoral neck by 4,9% from the baseline (p<0.05). Bisphosphonates therapy in postmenopausal women gives additional reduction of central systolic arterial pressure of 4.1 mm Hg with the tendency to improvement in the arterial stiffness. The dynamics of aortal stiffness was correlated with changers in intensity of bone remodeling (for N-terminal propeptides of type I procollagen (P1NP) p =0.47, p=0.019; for carboxyl-terminal telopeptide of collagen type I (CITP1) p=0.40, p=0.05) as well as systolic blood pressure (r=0.52, p=0.008). Conclusions. Bisphosphonate therapy and its combination with statins may influence the on parameters of blood pressure and aortic stiffness in women with postmenopausal osteoporosis.
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Баринова et al. (2014) studied this question.
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