Summary We compared Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein ( WFA + ‐M2 BP ) levels between patients with chronic hepatitis B (n=249) and chronic hepatitis C (n=386) based on the degree of liver fibrosis. We examined WFA + ‐M2 BP levels in patients with F4 (cirrhosis), F3 or more (advanced fibrosis) and F2 or more (significant fibrosis) in the two groups. We further examined the relationship between five fibrosis markers and the degree of fibrosis. The WFA + ‐M2 BP values ranged from 0.25 cut‐off index ( COI ) to 12.9 COI in patients with hepatitis B and 0.34–20.0 COI in patients with hepatitis C ( P <.0001). The median WFA + ‐M2 BP values in F4 in the two groups were 2.83 COI in patients with hepatitis B and 5.03 COI in patients with hepatitis C ( P =.0046). The median WFA + ‐M2 BP values in F3 or more in the two groups were 1.79 COI in patients with hepatitis B and 3.79 COI in patients with hepatitis C ( P <.0001). The median WFA + ‐M2 BP values in F2 or more in the two groups were 1.49 COI in the hepatitis B cohort and 3.19 COI in the hepatitis C group ( P <.0001). Among five liver fibrosis markers, WFA + ‐M2 BP had the highest correlation coefficient ( r s =.629) in terms of correlation with the degree of fibrosis in the patients with hepatitis C and had the second highest r s value (.415) in the hepatitis B group. Although WFA + ‐M2 BP could be a useful indicator of liver fibrosis, WFA + ‐M2 BP levels in the two groups significantly differed even in the same degree of fibrosis. Individual cut‐off values in each aetiology for the degree of fibrosis should be determined.
No takes yet. Share an insight, caveat, or question.
Nishikawa et al. (2016) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: