FDG PET/CT can help differentiate malignant cardiac sarcomas from benign myxomas by demonstrating abnormal metabolic uptake.
A 52-year-old man had shortness of breath and chest discomfort for 2 months. Chest CT and MRI showed a mass in the left atrium attached to the mitral annulus without obvious enhancement. Initial diagnosis was suspected of myxoma. Preoperative FDG PET/CT demonstrated the corresponding lesion with abnormal FDG uptake, indicating a malignancy. Finally, histopathologic examination revealed primary undifferentiated sarcoma.
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Wang et al. (2020) studied this question.
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