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To investigate reactive nitrogen species-mediated oxidative brain damage and antioxidant defense status in patients with acute bacterial meningitis.

January 22, 2002Neurology

Oxidative stress in bacterial meningitis in humans

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To investigate reactive nitrogen species-mediated oxidative brain damage and antioxidant defense status in patients with acute bacterial meningitis.
Immunohistochemical detection of nitrotyrosine and the lipid peroxidation marker 4-hydroxynonenal in brain autopsy tissue.
Quantification of cerebrospinal fluid (CSF) nitrotyrosine concentrations using ELISA.
Analysis of CSF and serum levels of ascorbic acid, uric acid, and allantoin using high-pressure liquid chromatography.
Tyrosine nitration and 4-hydroxynonenal staining increased markedly in inflammatory cells and blood vessels within the subarachnoid space during meningitis.
High CSF nitrotyrosine concentrations were associated with worse clinical outcomes on the Glasgow Outcome Score.
Elevated CSF nitrotyrosine occurred alongside depleted ascorbic acid and accelerated oxidation of uric acid into allantoin.

Authors

SKStefan KastenbauerGerman Society of Surgery UKUwe KoedelLMU Klinikum BBBernhard F. BeckerLudwig-Maximilians-Universität München

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Implication

Observational study reveals increased oxidative brain damage and antioxidant depletion in bacterial meningitis patients, highlighting reactive nitrogen species in disease pathophysiology.

Cite This Study

Kastenbauer et al. (2002) studied this question.

synapsesocial.com/papers/6a816b2b267334e2baf099ae https://doi.org/10.1212/wnl.58.2.186

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Implication

Observational study reveals increased oxidative brain damage and antioxidant depletion in bacterial meningitis patients, highlighting reactive nitrogen species in disease pathophysiology.

Oxidative stress in bacterial meningitis in humans

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Implication

Cite This Study

Oxidative stress in bacterial meningitis in humans

Key Points

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Implication

Cite This Study

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