Why the study?
Does left atrial thrombus morphology assessed by TEE predict cerebral/arterial embolism in patients with atrial fibrillation?
Does left atrial thrombus morphology assessed by TEE predict cerebral/arterial embolism in patients with atrial fibrillation?
Movable ball-type left atrial thrombi identified by TEE are associated with a significantly higher risk of cerebral or arterial embolism in patients with atrial fibrillation.
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Movable ball-type LA thrombi on TEE were associated with higher embolism risk in AF; hypothesis-generating for morphology-based stratification.
The current study was undertaken to clarify the relationship between cerebral/arterial embolism and the morphology of left atrial thrombi. Forty-one patients with atrial fibrillation and left atrial thrombi were followed for 1 year, using transesophageal echocardiography (TEE) to study how the shape, site, movability, number and maximum dimension of left atrial thrombi are related to embolism. Left atrial thrombi were classified by their shape and movability into movable ball (MB) type (n=13), fixed ball (FB) type (n=17) and mountain (MN) type (n=11). The thrombi were also classified by location into the interior section (n=3), middle section (n=8), and the entrance section (n=19) of the left atrial appendage, and the section outside of the left atrial appendage (n=11). The rate of embolism in the MB-type group was significantly higher than that in the other groups (ie, MB 76.9% vs FB 17.6% (p<0.01) vs MN 9.1%; p<0.01), which indicates that the MB-type thrombus is an important risk factor for cerebral/arterial embolism.
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Abe et al. (2000) studied this question.
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