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Megadose bromazepam and zolpidem dependence: two case reports of treatment with flumazenil and valproate. Quaglio G; Faccini M; Vigneau CV; Casari R; Mathewson S; LICATA, Manuela ; Lugoboni F. 2012 Abstract The risk of dependence from benzodiazepines (BZDs) has been well described. BZD dependence is usually treated with tapering of the medication, which may require several months. An alternative approach, the abrupt discontinuation of the medication and rapid detoxification using flumazenil, has been proposed (1–3). Anticonvulsants are increasingly being investigated as medications for a more rapid and safer BZD tapering
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Quaglio et al. (2012) studied this question.
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