Persistent oral infections of iVDPV2 in primary immune deficient patients present a potential risk for oral-oral and fecal-oral transmission.
Persistent iVDPV2 at dual sites may heighten transmission risk in immunodeficiency; leaves open questions on site-specific viral dynamics.
This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world.
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Weil et al. (2019) studied this question.
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