Key result
Sox17 deficiency plus angiotensin II induces vascular abnormalities resembling intracranial aneurysms in mice.
Why the study?
The hereditary basis of intracranial aneurysm remains poorly understood, and genetically modified animal models accurately reflecting IA pathogenesis have been lacking.
Sox17 deficiency under hypertensive conditions induces intracranial aneurysms in mice, providing a novel genetic model for studying IA pathogenesis and developing therapeutics.
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No immediate clinical impact for IA; leaves open whether endothelial Sox17 informs human risk or therapy.
Lee et al. (2015) studied Intracranial aneurysm. Sox17 deficiency and angiotensin II infusion was evaluated on Induction of vascular abnormalities resembling intracranial aneurysm. Sox17 deficiency combined with angiotensin II infusion in mice induces vascular abnormalities closely resembling intracranial aneurysms, suggesting it as a potential genetic factor for IA formation.
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