Why the study?
Angiosarcoma with malignant effusion is an uncommon and clinically aggressive entity that poses a diagnostic pitfall due to overlapping cytomorphologic features with metastatic adenocarcinoma.
Angiosarcoma with malignant effusion is a diagnostic pitfall with overlapping features with metastatic adenocarcinoma, requiring specific cytological and immunocytochemical markers for accurate diagnosis.
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Consider angiosarcoma in atypical malignant effusions; case report leaves open validation of proposed markers.
Angiosarcoma with malignant effusion is an uncommon yet clinically aggressive presentation, which poses as a diagnostic pitfall with its overlapping cytomorphologic features with metastatic adenocarcinoma. In this article, two cases reported in the literature were reviewed for cytology, immunocytochemistry, and clinical course. Key clinical hints, useful cytological features, and immunocytochemical markers in the diagnostic approach of this entity are presented.
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Lam et al. (2025) studied this question.
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