MANY attempts have been made to determine the effect of posterior pituitary extract on electrolyte excretion. Conflicting reports have appeared and conclusive data on the action of pitressin on the renal tubular transport of electrolytes in the dog are lacking. The present studies were undertaken to determine the effect of chronic pitressin administration on electrolyte excretion in normal dogs and in dogs with ascites produced by constriction of the thoracic inferior vena cava. The relation of the changes in electrolyte excretion to adrenocortical function in animals with ascites has been evaluated by injection of pitressin in adrenalectomized dogs with thoracic inferior caval constriction. methods After a control period of 2–3 weeks, pitressin tannate in oil (PTO) was administered in doses of 1–2.5 units twice daily to 1) two normal dogs (dogs 1 and 2), 2) two dogs with thoracic inferior vena cava constriction,
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Davis et al. (1954) studied this question.