Answers are grounded in this paper and cite their sources.
A concise and efficient synthetic method for alkynyl quinolines through TfOH‐promoted cascade 1,4‐conjugate addition/intramolecular annulation/aromatization process is established. By virtue of reactive aza‐o ‐AQM (in situ generated from modular propargylamine), this reaction proceeds smoothly to afford a variety of alkynyl quinolines in good to excellent yields. This transition‐metal‐free process features halogen groups tolerance, such as the −Cl, −Br, and −I groups; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of halogenated quinolines.
No takes yet. Share an insight, caveat, or question.
Tang et al. (2021) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: