October 1, 2010The Journal of Clinical PsychiatryOpen Access

Why Do You Need to Move Beyond First-Line Therapy for Major Depression?

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Population

Patients with major depression in primary care settings, including those with treatment-resistant depression.

Design

Review

Authors

LCLarry CulpepperUniversity of Pisa

Discussion

Member takes

Implication

May support stepped care and atypical antipsychotics in primary care for resistant depression; leaves open need for confirmatory RCTs.

Structured PICO

Population

Patients with major depression in primary care settings, including those with treatment-resistant depression.

Intervention

Moving beyond first-line therapy (e.g., atypical antipsychotics, stepped care, patient-centered medical home).

This review highlights the need for primary care clinicians to adopt new treatment options and systems, such as stepped care and atypical antipsychotics, for patients with treatment-resistant major depression.

Cite This Study

Larry Culpepper (2010) studied this question.

synapsesocial.com/papers/6a817857a0713f3198f0a2b3 https://doi.org/10.4088/jcp.9104su1c.01

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Why Do You Need to Move Beyond First-Line Therapy for Major Depression?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Why Do You Need to Move Beyond First-Line Therapy for Major Depression?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider