Why the study?
It is frequently overlooked that UCP1 is constitutively inactive without activation, leading to incorrect conclusions that increased brown or beige adipose tissue automatically enhances thermogenesis and produces beneficial metabolic effects.
Design
Review
Authors
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Increasing brown fat mass alone may not enhance thermogenesis; leaves open whether UCP1 activation strategies will yield clinical benefit.
Key points are not available for this paper at this time.
Li et al. (2022) studied this question.