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June 1, 2005Angewandte Chemie

Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes

Yujiro Hayashi Hiroaki Gotoh Takaaki Hayashi Mitsuru Shoji

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Abstract

Die direkte, katalytische, asymmetrische Michael-Addition von Aldehyden an Nitroolefine in Gegenwart eines chiralen Diphenylprolinolsilylether-Organokatalysators (siehe Schema) liefert hoch syn-diastereoselektiv die gewünschten 1,4-Addukte in nahezu optisch reiner Form und guter Ausbeute. TMS=Trimethylsilyl.

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Hayashi et al. (2005) studied this question.

synapsesocial.com/papers/6a817927e6814737203c25fb https://doi.org/10.1002/ange.200500599

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