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August 16, 2026Cell Proliferation0 citationsOpen Access

Liver Organoids for Disease Modeling and Regenerative Medicine Applications

Liver Organoids: From Disease Modelling to Regenerative Medicine

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Authors

TWTiepeng WangXQXiaotian QuJSJinhong Si

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Overview

Systematic review demonstrates advances in liver organoids for disease modeling and therapeutic transplantation, indicating substantial potential for precision hepatology and regenerative therapies.

Key Points

  • To systematically summarize fabrication strategies, disease-modeling applications, and regenerative potentials of liver organoids while addressing current translational challenges.
  • Reviewed technological developments in 3D liver organoid fabrication, endothelial co-culture, and prime editing systems.
  • Synthesized findings across metabolic disease modeling, viral infection platforms, patient-derived tumor biobanks, and bioartificial liver support devices.
  • Endothelial co-culture generated vascularized liver organoids with endothelial coverage exceeding 85%, while prime editing corrected pathogenic mutations without detectable genome-wide off-target effects.
  • Organoid platforms successfully modeled MASLD pathogenesis, verified the lipid-lowering efficacy of semaglutide, and supported complete replication cycles of HEV, SARS-CoV-2, and dengue virus.
  • Encapsulated organoids and the UTOpiA bioartificial liver rescued acute liver failure in preclinical animal models, though functional maturity and protocol standardization remain primary translational barriers.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a8179bcf2fb91fc834ad10ehttps://doi.org/10.1111/cpr.70268
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