Assessment of Wound Healing Complications With a Lower Cost Outpatient Wound Management Protocol: A Pragmatic Randomized Clinical Trial in Dogs

Alexandra Kuvaldina; Galina Hayes; Ali Aly; Sarah Robbins; Nathan Peterson

doi:10.1111/vec.70151

August 14, 2026Journal of Veterinary Emergency and Critical Care

Assessment of Wound Healing Complications With a Lower Cost Outpatient Wound Management Protocol: A Pragmatic Randomized Clinical Trial in Dogs

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Key Points

To determine whether a lower-cost outpatient wound management protocol in dogs provides noninferior wound complication rates while reducing veterinary visits and fecal microbiota disruption compared to gold standard care.
Pragmatic noninferiority randomized controlled trial conducted at a veterinary teaching hospital enrolling 58 dogs quasi-randomized by admission date.
Gold standard group (n = 33) received sterile gloves, 8-psi sterile saline lavage, No. 40 blade hair clipping, interrupted nylon sutures, and 7 days of potentiated amoxicillin.
Lower-cost group (n = 25) received non-sterile exam gloves, tap water gravity lavage, No. 10 blade hair clipping, continuous poliglecaprone-25 closure, and 3 days of potentiated amoxicillin, with blinded owner and veterinarian follow-up.
The trial was stopped early because wound infections occurred in 40% (10/25) of the lower-cost group versus 12.5% (4/32) of the gold standard group (risk difference: 27.5%, 95% CI: 5.1–49.8; RR: 3.20, 95% CI: 1.14–9.01; p = 0.03).
Follow-up veterinary visits did not differ significantly between the two groups (p = 0.3).
The lower-cost protocol demonstrated less disruption of fecal microbiota diversity compared with the gold standard protocol (delta Shannon diversity index: 1.16 ± 0.28 [n = 9] vs. 0.76 ± 0.27 [n = 16]; p = 0.002).

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Implication

Randomized noninferiority trial reveals higher infection rates with a lower-cost wound protocol in dogs, indicating standard sterile procedures remain necessary.

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Kuvaldina et al. (2026) studied this question.

synapsesocial.com/papers/6a8179eff2fb91fc834ad6a1 https://doi.org/10.1111/vec.70151

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Assessment of Wound Healing Complications With a Lower Cost Outpatient Wound Management Protocol: A Pragmatic Randomized Clinical Trial in Dogs

Key Points

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Implication

Discussion

Cite This Study

Assessment of Wound Healing Complications With a Lower Cost Outpatient Wound Management Protocol: A Pragmatic Randomized Clinical Trial in Dogs

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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