Preclinical study demonstrates that nanofabricated shikonin accelerates burn wound closure in diabetic rats, suggesting its therapeutic potential for enhanced tissue regeneration.
BACKGROUND: Diabetic burn wounds are challenging comorbid conditions to heal, hence shikonin, a traditional phytoconstituent was nanofabricated in the present study. This study is the continuation of our previously published work including shikonin-loaded nanoemulsion against wound pathogens. OBJECTIVE: Current work aims to further prepare electrospun scaffolds to promote wounded skin regeneration. METHODS: model, western blotting (protein expression of MMP-9), soluble collagen and MMP-9 ELISA kit assays, molecular docking and simulations studies were used to evaluate pharmacodynamic stability. RESULTS: The developed scaffolds exhibited chemical stability, improved aqueous solubility with average diameter of 235 ± 23 nm. The wound area got remarkably decreased (4.923 ± 0.935%) with high collagen content (88.515 ± 2.23%) and lower MMP-9 content (6.726 ± 0.820%) than the comparable groups. CONCLUSION: The present study displayed the developed system with remarkable wound healing potential.
No takes yet. Share an insight, caveat, or question.
Kaur et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: