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August 16, 2026Pest Management ScienceOpen Access

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

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Authors

LCLuan CuttiEPEric L. PattersonTGTodd A. Gaines

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Overview

Scientific review synthesizes molecular herbicide resistance mechanisms and metabolic pathways in weed populations, highlighting diagnostic-driven strategies to prevent resistance evolution.

Key Points

  • Synthesize current molecular insights on target-site and non-target-site herbicide resistance to establish a framework for mechanism-informed weed management.
  • Synthesized literature on target-site resistance mutations across major herbicide modes of action and their associated cross-resistance patterns.
  • Compiled a comprehensive catalog of metabolic genes and evaluated environmental influences modulating non-target-site resistance expression.
  • Assessed approaches for integrating molecular diagnostics and genomic tools into agricultural field stewardship.
  • Identified mutation- and species-specific cross-resistance profiles that enable rational herbicide selection beyond broad mode-of-action exclusion.
  • Delivered a unified overview of all metabolic genes conferring non-target-site resistance alongside key environmental modulators.
  • Established a translational framework connecting molecular diagnostic data directly to field-scale resistance mitigation tactics.

Cite This Study

Cutti et al. (2026) studied this question.

synapsesocial.com/papers/6a817a11f2fb91fc834adb1dhttps://doi.org/10.1002/ps.71187
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