What question did this study set out to answer?

To evaluate the efficacy and molecular mechanism of ONC201 as a radiosensitizing agent in small-cell lung cancer.

August 16, 2026iScienceOpen Access

ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway

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Authors

YYYuheng YanTongji Hospital ZXZhaolin XuTongji Hospital ZXZiyang XuWuhan Polytechnic University

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Implication

Preclinical study demonstrates that ONC201 improves radiation sensitivity and induces apoptosis in small-cell lung cancer by suppressing FAK signaling, highlighting its potential as a radiosensitizer.

Key Points

To evaluate the efficacy and molecular mechanism of ONC201 as a radiosensitizing agent in small-cell lung cancer.
Assessed small-cell lung cancer cell proliferation, migration, invasion, cell-cycle progression, and apoptosis following ONC201 treatment.
Investigated the combined effects of ONC201 and radiation on cellular radiosensitivity and focal adhesion kinase (FAK) signaling pathway activity.
ONC201 treatment significantly suppressed proliferation, migration, and invasion while inducing apoptosis and cell-cycle arrest in small-cell lung cancer cells.
Combining ONC201 with radiotherapy enhanced radiosensitivity, augmented G2/M phase arrest, and increased apoptosis via suppression of FAK signaling.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/6a817a60f2fb91fc834ae30e https://doi.org/10.1016/j.isci.2026.117202

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ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

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