What question did this study set out to answer?

To synthesize fused pyrano-thiazole-2-one derivatives via an eco-friendly one-pot microwave protocol and evaluate their potential as antitubercular agents.

August 16, 2026Discover Chemistry.Open Access

Antitubercular evaluation and synthesis of fused pyrano-thiazole-2-one derivatives via green and efficient protocol

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Authors

SPSantosh S. Pohare PMPrashant P. Mogle MGMilind V. Gaikwad

Discussion

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Overview

Experimental study demonstrates potent growth inhibition by novel pyrano-thiazole-2-one derivatives against Mycobacterium smegmatis, highlighting their potential as green antitubercular drug leads.

Key Points

To synthesize fused pyrano-thiazole-2-one derivatives via an eco-friendly one-pot microwave protocol and evaluate their potential as antitubercular agents.
Synthesized derivatives 4a–l via a one-pot reaction of substituted aromatic aldehydes, malononitrile, and thiazolidine-2,4-dione in PEG-400 with BEC catalyst under microwave irradiation (210 W, 1 hour), characterizing structures with IR, NMR, and mass spectrometry.
Evaluated antitubercular potency against Mycobacterium smegmatis (ATCC 19420) across concentrations from 6.25 to 100 µg/mL using the Microplate Alamar Blue Assay and performed molecular docking against target protein PDB ID: 2H7M.
The microwave-assisted green synthetic method produced compound yields between 86% and 92%.
Compound 4b demonstrated the highest antitubercular activity with a minimum inhibitory concentration (MIC) of 6.19 µg/mL, followed by 4c (11.01 µg/mL), 4h (11.93 µg/mL), and 4g (12.19 µg/mL).
Molecular docking verified strong binding interactions between the active derivatives and the target bacterial protein.

Cite This Study

Pohare et al. (2026) studied this question.

synapsesocial.com/papers/6a817a72f2fb91fc834ae43d https://doi.org/10.1007/s44371-026-00914-z

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August 16, 2026Discover Chemistry.Open Access

Antitubercular evaluation and synthesis of fused pyrano-thiazole-2-one derivatives via green and efficient protocol

View Full Paper

Ask AI

Bookmark

Authors

SPSantosh S. Pohare PMPrashant P. Mogle MGMilind V. Gaikwad

Discussion

Member takes

Overview

Experimental study demonstrates potent growth inhibition by novel pyrano-thiazole-2-one derivatives against Mycobacterium smegmatis, highlighting their potential as green antitubercular drug leads.

Key Points

To synthesize fused pyrano-thiazole-2-one derivatives via an eco-friendly one-pot microwave protocol and evaluate their potential as antitubercular agents.
Synthesized derivatives 4a–l via a one-pot reaction of substituted aromatic aldehydes, malononitrile, and thiazolidine-2,4-dione in PEG-400 with BEC catalyst under microwave irradiation (210 W, 1 hour), characterizing structures with IR, NMR, and mass spectrometry.
Evaluated antitubercular potency against Mycobacterium smegmatis (ATCC 19420) across concentrations from 6.25 to 100 µg/mL using the Microplate Alamar Blue Assay and performed molecular docking against target protein PDB ID: 2H7M.
The microwave-assisted green synthetic method produced compound yields between 86% and 92%.
Compound 4b demonstrated the highest antitubercular activity with a minimum inhibitory concentration (MIC) of 6.19 µg/mL, followed by 4c (11.01 µg/mL), 4h (11.93 µg/mL), and 4g (12.19 µg/mL).
Molecular docking verified strong binding interactions between the active derivatives and the target bacterial protein.

Cite This Study

Pohare et al. (2026) studied this question.

synapsesocial.com/papers/6a817a72f2fb91fc834ae43d https://doi.org/10.1007/s44371-026-00914-z

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