Announcing The Lancet Regional Health—Europe series on the alarming surge of early-onset colorectal cancer: a multidisciplinary call to action

The rising incidence of early-onset colorectal cancer (EOCRC), defined as a diagnosis in adults younger than 50 years, has emerged as a critical global public health challenge.1 While colorectal cancer (CRC) rates in older populations have stabilized or declined due to successful screening programs, the incidence among younger adults is surging at an unprecedented rate.2 Projections suggest that by 2030, one-third of all colorectal cancers will be diagnosed in individuals under the age of 50.3 This “unprecedented tumor epidemic” might be driven by a significant birth cohort effect, suggesting that generational shifts in environmental exposures, lifestyle factors, such as obesity, westernized diets, antibiotic usage, and potentially associated alterations in the microbiome are reshaping the epidemiological landscape of CRC.