The Treatment of Renal Osteodystrophy

Editorials1 November 1966The Treatment of Renal OsteodystrophyS. W. STANBURY, M.D., F.R.C.P.S. W. STANBURY, M.D., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1133 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pathogenesis of azotemic osteodystrophy is still uncertain. The demonstration of impaired intestinal absorption of calcium (1, 2), the occurrence of rickets and osteomalacia (3, 4), and their cure by large amounts of vitamin D are all compatible with an acquired insensitivity to the biological effects of vitamin D (1-5). Hypocalcemia when present is associated with reduced osseous responsiveness to the calcemic action of exogenous parathyroid hormone (6), a functional abnormality also found in simple vitamin D deficiency (7). A degree of secondary hyperparathyroidism is to be expected with vitamin D deficiency, but the osseous manifestations of parathyroid activity are...References1. DENTHARPERPHILPOT CECMGR: Treatment of renal-glomerular osteodystrophy. Quart. J. Med. 30: 1, 1961. MedlineGoogle Scholar2. STANBURYLUMB SWGA: Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus and nitrogen metabolism in rickets, osteomalacia and hyperparathyroidism complicating chronic uremia and in the osteomalacia of the adult Fanconi syndrome. Medicine (Balt.) 41: 1, 1962. CrossrefMedlineGoogle Scholar3. STANBURY SW: Azotaemic renal osteodystrophy. Brit. Med. Bull. 13: 57, 1957. CrossrefMedlineGoogle Scholar4. STANBURY SW: Bony complications of renal disease, in Renal Disease, edited by BLACK, D. A. K. Blackwell, Oxford, 1962, p. 508. (Also 2nd ed., in press, 1966.) Google Scholar5. FLETCHERJONESMORGAN RFJHDB: Bone disease in chronic renal failure. Quart. J. Med. 32: 321, 1963. MedlineGoogle Scholar6. 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ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.22. Chirurgie der Epithelkörperchen 1 November 1966Volume 65, Issue 5Page: 1133-1138KeywordsCalciumHyperparathyroidismHypocalcemiaParathyroidParathyroid hormonePathogenesisVitamin DVitamin D deficiency Issue Published: 1 November 1966 PDF DownloadLoading ...