Why the study?
Does the driving frequency of a biventricular assist device affect baroreceptor-mediated sympathetic outflow in an adult mongrel dog model?
Does the driving frequency of a biventricular assist device affect baroreceptor-mediated sympathetic outflow in an adult mongrel dog model?
The natural heart beat frequency may be the optimal setting for biventricular assist devices to maintain normal baroreflex transfer of hemodynamic rhythm to sympathetic outflow.
Answers are grounded in this paper and cite their sources.
May support native-frequency BVB driving to preserve baroreflex coherence in dogs; hypothesis-generating for clinical device settings.
To investigate the drive condition of the artificial heart from a neurophysiological point of view, the dynamic transduction characteristics of the baroreflex system were analyzed by means of sympathetic neurograms. Two pneumatically actuated ventricular assist devices were implanted as biventricular bypasses (BVBs) in adult mongrel dogs to compare the natural heart circulation and prosthetic circulation. After BVB pumping was initiated, the natural heart was electrically fibrillated. Renal sympathetic nerve activity (RSNA) was recorded to analyze sympathetic outflow. Coherence function between the arterial pressure and RSNA was calculated to evaluate the linearity of the baroreflex system. The largest peak coherency was observed when BVB was driven at the frequency of natural heart beat prior to electrical fibrillation, which suggests that the baroreflex system shows the largest linearity at this frequency. These results suggest the possibility that the natural heart beat frequency is the setting frequency at which the baroreflex system transfers the hemodynamic rhythm to the sympathetic outflow.
No takes yet. Share an insight, caveat, or question.
Yambe et al. (1993) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: