Key result
High HDL-C levels were associated with a significantly lower risk of obstructive coronary artery disease (OR 0.584) compared to low HDL-C levels in asymptomatic diabetics with optimal glycemic control.
Why the study?
The benefit of high HDL-C levels against coronary atherosclerosis risk after achieving optimal glycemic control in diabetic patients remains uncertain.
Does a high HDL-C level reduce the risk of obstructive CAD on CCTA in asymptomatic diabetics who have achieved optimal glycemic control?
Observational (n=1,114)
No
Does a high HDL-C level reduce the risk of obstructive CAD on CCTA in asymptomatic diabetics who have achieved optimal glycemic control?
Maintaining high HDL-C levels is associated with a reduced risk of obstructive coronary artery disease in asymptomatic diabetic patients, but only if they have achieved optimal glycemic control (HbA1C <7.0%).
High HDL-C may mark lower obstructive CAD risk in glycemic-controlled diabetics; hypothesis-generating and should not yet change practice.
The benefit of a high level of high-density lipoprotein cholesterol (HDL-C) against coronary atherosclerosis risk after achieving optimal glycemic control (OGC) in diabetics remains uncertain. We aimed to evaluate the association between HDL-C and obstructive coronary artery disease (CAD) according to OGC status in diabetics. We analyzed 1,114 asymptomatic diabetics who underwent coronary computed tomographic angiography in a health examination. OGC was defined as hemoglobin A1C <7.0%. Obstructive CAD was defined as the presence of plaques with ≥50% stenosis. Patients with a high HDL-C level (≥40 mg/dL and ≥50 mg/dL in males and females, respectively) showed a lower prevalence of obstructive CAD than those with a low HDL-C level in the OGC group (8.9% vs. 14.4%; p = 0.046), but not in the non-OGC group (22.3% vs. 23.2%, p = 0.850). Multiple logistic regression models showed that the risk for obstructive CAD was lower in patients with a high HDL-C level than in those with a low HDL-C level in the OGC group (odds ratio: 0.584, 95% confidence interval: 0.343-0.995; p = 0.048), but not in the non-OGC group. In conclusion, it may be necessary to maintain a high HDL-C level to reduce the risk of obstructive CAD in asymptomatic diabetics after OGC is achieved.
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Park et al. (2019) conducted an observational in Asymptomatic diabetes mellitus (n=1,114). High HDL-C level vs. Low HDL-C level was evaluated on Obstructive coronary artery disease (presence of plaques with ≥50% stenosis) in patients with optimal glycemic control (OR 0.584, 95% CI 0.343-0.995, p=0.048). High HDL-C levels were associated with a significantly lower risk of obstructive coronary artery disease (OR 0.584) compared to low HDL-C levels in asymptomatic diabetics with optimal glycemic control.
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