Key result
Patient-prosthesis mismatch did not prevent 12-month improvement in LV function and metabolism after aortic valve replacement, with impaired diastolic filling correlating with increased LV mass (mismatch R2=-0.71, p=0.002).
Why the study?
Does patient-prosthesis mismatch impair the improvement of myocardial metabolism and left ventricle function in patients undergoing aortic valve replacement for pure aortic stenosis?
Cohort (n=30)
Does patient-prosthesis mismatch impair the improvement of myocardial metabolism and left ventricle function in patients undergoing aortic valve replacement for pure aortic stenosis?
Patient-prosthesis mismatch does not appear to impair the early improvement in left ventricular function and myocardial metabolism following aortic valve replacement for pure aortic stenosis.
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PPM may not preclude early LV recovery after AVR; leaves open whether mismatch reduction improves diastolic filling and mass regression.
Mannacio et al. (2011) conducted a cohort in Pure aortic stenosis (n=30). Patient-prosthesis mismatch vs. No patient-prosthesis mismatch was evaluated on Myocardial metabolism and left ventricle function. Patient-prosthesis mismatch did not prevent 12-month improvement in LV function and metabolism after aortic valve replacement, with impaired diastolic filling correlating with increased LV mass (mismatch R2=-0.71, p=0.002).