Key result
Low and high levels of LDL-c were associated with poorer survival and walking ability at 1 year compared to middle levels of LDL-c in geriatric patients after hip fracture surgery (p < 0.001).
Why the study?
The study aimed to explore the association between lipids and the survival and walking ability of hip fractures in geriatric patients after surgery.
Do low or high levels of LDL-c affect survival and walking ability in geriatric patients after hip fracture surgery compared to middle levels?
Cohort
Do low or high levels of LDL-c affect survival and walking ability in geriatric patients after hip fracture surgery compared to middle levels?
p-value: p=<0.001
Both low and high levels of LDL-c are associated with worse survival and walking ability in geriatric patients following hip fracture surgery, demonstrating a paradoxical U-shaped relationship.
U-shaped LDL-c association after hip fracture warrants caution in lipid targets; leaves open need for prospective trials before practice change.
Background: We aimed to explore the association between lipids and the survival and walking ability of hip fractures in geriatric patients after surgery. Methods: Restricted cubic spline (RCS) was established to explore the nonlinear relationship between lipids and 1-year mortality of hip fractures, and the cut-off points were also determined by RCS. Then, the patients were divided into three groups: low, middle, and high levels of LDL-c. Then, the survival and walking ability of patients from different groups were compared, and the Cox regression and Logistics regression were used to identify the relationships between lipids and the survival and walking ability of hip fractures. Results: The patients with middle levels of LDL-c had a significantly high survival probability than those with low or high levels of LDL-c (p < 0.001). The patients with low levels of LDL-c and with high levels of LDL-c may have a poor prognosis compared with patients with middle levels of LDL-c in 6-month mortality, 6-month free walking ability, 1-year mortality, and 1-year free walking ability (All p < 0.05). Conclusion: Low and high levels of LDL-c may both relate to the poor survival and walking ability of hip fractures.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2023) conducted a cohort in Hip fractures in geriatric patients after surgery. Low and high levels of LDL-c vs. Middle levels of LDL-c was evaluated on Survival probability and walking ability (p=<0.001). Low and high levels of LDL-c were associated with poorer survival and walking ability at 1 year compared to middle levels of LDL-c in geriatric patients after hip fracture surgery (p < 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: