Suppression of Schistosome Granuloma Formation by Malaria in Mice

Plasmodium berghei yeolii infection in mice suppressed granuloma formation around Schistosoma mansoni eggs in the lungs. This suppressive effect was observed as early as 4 days after schistosome eggs were injected into malaria-infected mice and the maximum suppressive effect was seen by the 16th day. At this time granulomas in control mice than in mice infected with malaria. These data suggest that malaria has a direct influence on an immunologic reaction of the delayed hypersensitivity type. There was no significant difference in the level of antibodies, specific for schistosome eggs, in the sera of the malaria-infected mice as compared to mice injected with S. mansoni eggs alone.