Key result
Long-term near-normoglycemic control in type I diabetics was associated with persistently elevated platelet factor 4 (15.8 vs 8.9 ng/ml) and beta-thromboglobulin compared to healthy controls (p<=0.05).
Why the study?
Does long-term near-normoglycemic control reduce platelet activation in type I diabetics with chronic complications compared to healthy controls?
Observational (n=64)
Does long-term near-normoglycemic control reduce platelet activation in type I diabetics with chronic complications compared to healthy controls?
Platelet activation remains elevated in type I diabetics with microangiopathy despite long-term near-normoglycemic control, indicating persistent vascular risk.
Answers are grounded in this paper and cite their sources.
Persistent platelet activation in type 1 diabetes despite near-normoglycemia; leaves open whether adjunctive therapies can mitigate ongoing vascular risk.
A prethrombotic state with altered, hyperactive platelets may contribute to the development of diabetic late complications. Whether increased platelet 'in vivo' activation can be reduced by tight metabolic control is controversial. We studied plasma markers of platelet activation in 64 long-term, microangiopathic type I diabetics after at least 18 months of intensive treatment for near-normoglycemia. Both platelet factor 4 and beta-thromboglobulin proved to be significantly (p less than or equal to 0.05) elevated in comparison with healthy controls: 15.8 (sdf 2)/77.6 (sdf 1.9) vs. 8.9 (sdf 1.6)/45.1 (sdf 2) ng/ml (sdf = standard deviation factor). We found no significant correlations with any metabolic parameter (actual blood glucose, mean blood glucose, HbA1, triglycerides, cholesterol) or with the duration of intensive treatment. It is therefore concluded, that platelet 'in vivo' activation takes place in type I diabetics even after long-term near-normoglycemic control. This deviation could be regarded as indicator of an additional risk for the development of vascular complications.
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Tschoepe et al. (2009) conducted an observational in Type I diabetes with chronic complications (n=64). Long-term near-normoglycemic control in type I diabetes vs. Healthy controls was evaluated on Platelet factor 4 (ng/ml) (p=<=0.05). Long-term near-normoglycemic control in type I diabetics was associated with persistently elevated platelet factor 4 (15.8 vs 8.9 ng/ml) and beta-thromboglobulin compared to healthy controls (p<=0.05).
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