Hproliferating.It is convenient to refer to such clones and the immunological patterns they carry as " forbidden " clones or " forbidden " patterns, and to regard the mechanism by which they are eliminated as part of the general homoeostatic control of body structure and function.A wide variety of medical conditions in the body represent the partial failure of homoeostatic mechanisms -auto-immune disease can be interpreted best as another example of partial and often temporary failure of one such mechanism.Instead of being eliminated certain forbidden clones of cells find opportunity to proliferate and, in reacting with the antigen involved, inflict damage on the body.
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S. Osnes (1959) studied this question.
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