Exercise and cardiomyocyte regeneration

Cardiovascular disease is the most common cause of death. Many researchers have evaluated the effect of exercise on heart function improvement, but studies about how exercise can affect heart regeneration are rare. Most of the previous studies only assess biomarkers that indicate heart damage. GATA-4 Transcription Factor is one of the transcription factors that form heart cells, showing the heart's ability to function properly under pressure. Cardiac-restricted zinc-finger TF GATA-4 is a survival factor that can break the vicious cycle of post-MI heart failure through increased myocardial angiogenesis, decreased apoptosis, and increased c-kit cell generation. Further research is needed because of its critical role in heart regeneration, whether GATA-4 can be used as an excellent cardiac biomarker in the future, and how the role of exercise or physical exercise on GATA-4 protein and its expression in cardiac regeneration.