siRNA: A Promising New Tool for Future Breast Cancer Therapy

Breast cancer remains a major health concern as it continues to be both the leading cause of cancer-related deaths and most commonly diagnosed form of cancer among women. Recently, RNAi (RNA interference)-based gene therapy has gained attention for its sequence-specific mechanism of gene silencing. RNAi may be induced with the use of short interfering RNAs (siRNAs), which are generated from double-stranded RNA (dsRNA) precursors. Although siRNA has its limitations, siRNA shows enormous potential as a promising tool for the regulation of disease-associated genes, including oncogenes and tumor suppressor genes. In this review, we will discuss the approaches, implications, and challenges of siRNA-mediated RNAi gene therapy regarding various targets of breast cancer.