Why the study?
Can endothelial immunohistochemical markers differentiate a massive hemorrhagic functional adrenal adenoma from an angiosarcoma?
Can endothelial immunohistochemical markers differentiate a massive hemorrhagic functional adrenal adenoma from an angiosarcoma?
Endothelial immunohistochemical markers are useful diagnostic adjuncts in differentiating reactive hemorrhagic/thrombotic adrenal lesions from angiosarcoma.
May support adenoma over angiosarcoma in hemorrhagic adrenal lesions; leaves open validation in larger series.
We report the case of a massive hemorrhagic/thrombosed functional adrenal adenoma, a very uncommon mass lesion of the adrenal gland. The lesion contained large areas that histologically mimicked the pattern of an angiosarcoma. Immunoperoxidase staining confirmed that the vascular lining cells were positive for vimentin and negative for three vascular markers (factor VIII antigen, Ulex europaeus agglutinin I, thrombomodulin), cytokeratin, keratin, epithelial membrane antigen, and S100 antigen. Endothelial immunohistochemical markers can be useful as a diagnostic adjunct in differentiating this type of reactive hemorrhagic/thrombotic lesion from angiosarcoma.
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Granger et al. (1991) studied this question.
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