The Marihuana-Induced "Social High"

Ten healthy freshman medical students who had previous extensive experience with marihuana smoking were allowed to inhale the compound in the laboratory until they had reached their usual "high." The observed overall effects were mild or minimal. In the electroencephalogram, there occurred a slight but statistically significant shift toward slower α-frequencies. There were no significant changes in cerebral evoked responses. Results of the neurological examination remained normal. Vibratory sense appreciation improved slightly. Mental status examination showed a slight decrease in intellectual efficiency, some excess jocularity, and a slight loosening of associations. Bender-Gestalt drawings were executed slightly more poorly after drug inhalation than before. It is concluded that the subjective pleasure and relaxation which are experienced as a result of marihuana smoking are accompanied by a very slight decrease in highest cortical functions.