Key result
ProBNPage was independently associated with multiple age-related impairments, including myocardial infarction (OR 1.08), often more strongly than chronological age.
Why the study?
While proBNPage is strongly associated with chronological age, all-cause mortality, and disease count, whether it is associated with other manifestations of aging compared with other biomarkers was unknown.
Is proBNPage associated with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults?
Cross-Sectional (n=1,117)
No
Is proBNPage associated with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults?
ProBNPage, a surrogate of biological age derived from NT-proBNP, is independently associated with multiple cardiovascular, physical, and psychological manifestations of aging, often more strongly than chronological age.
May support proBNPage for biological age assessment in older adults; hypothesis-generating and requires prospective validation.
NT-proB-type natriuretic peptide (NT-proBNP) serum concentration can be transformed by simple formulas into proBNPage, a surrogate of biological age strongly associated with chronological age, all-cause mortality, and disease count. This cross-sectional study aimed to assess whether proBNPage is also associated with other manifestations of the aging process in comparison with other variables. The study included 1117 noninstitutionalized older adults (73.1 ± 5.6 years, 537 men). Baseline measurements of serum NT-proBNP, erythrocyte sedimentation rate, hemoglobin, lymphocytes, and creatinine, which have previously been shown to be highly associated with both age and all-cause mortality, were performed. These variables were compared between subjects with and without manifestations of cardiovascular impairment (myocardial infarction (MI), stroke, peripheral artery disease (PAD), arterial revascularizations (AR)), physical impairment (long step test duration (LSTD), walking problems, falls, deficit in one or more activities of daily living), and psychological impairment (poor self-rating of health (PSRH), anxiety/depression, Mini Mental State Examination (MMSE) score < 24). ProBNPage (years) was independently associated (OR, 95% CI) with MI (1.08, 1.07-1.10), stroke (1.02, 1.00-1.05), PAD (1.04, 1.01-1.06), AR (1.06, 1.04-1.08), LSTD (1.03, 1.02-1.04), walking problems (1.02, 1.01-1.03), and PSRH (1.02, 1.01-1.02). For 5 of these 7 associations, the relationship was stronger than that of chronological age. In addition, proBNPage was univariately associated with MMSE score < 24, anxiety/depression, and falls. None of the other variables provided comparable performances. Thus, in addition to the known associations with mortality and disease count, proBNPage is also associated with cardiovascular manifestations as well as noncardiovascular manifestations of the aging process.
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Muscari et al. (2021) conducted a cross-sectional in Age-related cardiovascular, physical, and psychological impairment (n=1,117). proBNPage vs. Chronological age was evaluated on Myocardial infarction (MI) (OR 1.08, 95% CI 1.07-1.10, p=<0.0001). ProBNPage was independently associated with multiple age-related impairments, including myocardial infarction (OR 1.08), often more strongly than chronological age.
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