Self-Reported Physical Activity, QoL, Cardiac Function, and Cardiorespiratory Fitness in Women With HER2+ Breast Cancer

Figures

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  Central Illustration. Physical Activity, QoL, and Cardiac Function with Anthracyclines & Trastuzumab The nadirs of moderate to vigorous physical activity (MVPA) level, quality of life (QoL), and cardiac function measures occurred either after anthracycline or within 6 months of trastuzumab therapy initiation. Higher self-reported MVPA was associated with better QoL and cardiac function measures during treatment and higher post-treatment cardiorespiratory fitness in participants with human epidermal growth factor receptor 2–positive breast cancer. Cardiopulmonary exercise testing was performed after trastuzumab therapy.

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  Figure 1. Time Profiles of MVPA and QoL Over the Treatment Period Nadir values for (A) moderate to vigorous physical activity (MVPA) and (B to F) quality of life (QoL) measures occurred at time points 2 and 3. Error bars represent 95% CIs, on the basis of generalized estimation equation model with natural cubic splines. P values reflect changes over the entire observation period. MLHFQ = Minnesota Living With Heart Failure Questionnaire; VAS = visual analogue score.

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  Figure 2. Proportion of Active Participants at Each Time Point During Treatment Active participants engaged in ≥90 minutes of moderate to vigorous physical activity. The proportion meeting this target was the lowest at time points 2 and 3. ACSM = American College of Sports Medicine.

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  Figure 3. Mean Changes From Baseline for MVPA and QoL Largest changes in (A) MVPA and (B to F) QoL measures occurred at time points 2 and 3. Error bars represent 95% CIs, on the basis of a generalized estimating equations model with natural cubic splines. P values reflect changes over the entire observation period. Abbreviations as in Figure 1.

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  Figure 4. CMR LVEF and Echocardiographic Measures During Treatment Nadir values for (A) cardiac magnetic resonance (CMR), (B) 3 dimensional (3D) left ventricular ejection fraction (LVEF), and (C) global longitudinal strain (GLS) (absolute values) occurred at time points 3 and 4. Peak values of (D) E/e’ ratio and (E) E/A ratio occurred at time point 5. Error bars represent 95% CIs, on the basis of a generalized estimating equations model with natural cubic splines. P values reflect changes over the entire observation period. E/A = ratio of early to late mitral inflow diastolic velocities; E/e′ = ratio of mitral inflow early diastolic velocity and mean of the mitral annular medial and lateral velocities (used as marker of left ventricular filling pressures).