Key result
Enteroviral meningitis was associated with more frequent headache and enteric symptoms, while non-enteroviral meningitis had a significantly higher rate of seizures (8.5% vs 0.5%).
Why the study?
The purpose was to analyze the differences between enteroviral meningitis and non-enteroviral aseptic meningitis in children.
Does enteroviral meningitis differ from non-enteroviral aseptic meningitis in clinical presentation and outcomes in children?
Observational (n=303)
No
Does enteroviral meningitis differ from non-enteroviral aseptic meningitis in clinical presentation and outcomes in children?
Absolute Event Rate: 0.5% vs 8.5%
p-value: p=0.0002
In children with aseptic meningitis, enteroviral etiology is most common and has a benign course with prominent gastrointestinal symptoms, whereas non-enteroviral cases are associated with more severe neurological symptoms like seizures.
Alerts to higher seizure risk in non-enteroviral pediatric meningitis; leaves open prospective validation before guiding management.
Purpose: Meningitis is an acute childhood infection caused by viral or bacterial infection. The purpose of the present study is to analyze the differences between enteroviral meningitis and non-enteroviral aseptic meningitis. Methods: From January 2013 to December 2016, we retrospectively reviewed the medical records of a total of 303 aseptic meningitis patients who visited Wonju Severance Christian Hospital. We examined demographics of all patients and analyzed serologic and cerebrospinal fluid tests, clinical symptoms, and outcomes. Results: Of a total of 303 patients, 197(65.0%) were male, and the most cases occurred from June to November (91.8%). The most common pathogen of meningitis was found to be enterovirus (65.0%). According to the etiology, the enteroviral meningitis group had significantly more headache and enteric symptoms (P=0.0003 and P=0.0013, respectively). Furthermore, the non-enteroviral meningitis group showed pleocytosis in the cerebrospinal fluid and a significantly higher rate of seizure at 1 to 4 years (P=0.0360 and P=0.0002, respectively). Conclusion: In this study, enteroviral meningitis was the most common and the prognosis was good. When compared between two groups, neurological symptoms were frequent in patients with non-enteroviral meningitis in groups 1 to 4 years.
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Cho et al. (2018) conducted an observational in Aseptic meningitis (n=303). Enterovirus infection vs. Non-enteroviral infection was evaluated on Seizure occurrence (p=0.0002). Enteroviral meningitis was associated with more frequent headache and enteric symptoms, while non-enteroviral meningitis had a significantly higher rate of seizures (8.5% vs 0.5%).
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