High Resolution Image Download MS PowerPoint Slide Optimizing fed-batch fermentation strategies is key to maximizing bioprocess efficiency. While mathematical modeling can aid process design, its complexity often limits accessibility for experimental scientists. We present FedBatchDesigner, a user-friendly web tool for optimizing fed-batch processes with a growth-arrested production stage. With minimal input requirements, FedBatchDesigner enables rapid exploration of a process’s titer, rate, and yield (TRY) landscape for constant, linear, and exponential feeding strategies. Interactive visualizations allow users to assess trade-offs between productivity and titer, supporting rational decision-making without the need for extensive modeling expertise. We demonstrate FedBatchDesigner ’s utility via two case studies: synthesis of (i) l -valine with a microaerobic production stage in Escherichia coli and (ii) ethanol under nitrogen starvation in Saccharomyces cerevisiae . FedBatchDesigner is freely available at https://chemnettools.anc.univie.ac.at/FedBatchDesigner, with the source code provided at https://github.com/julibeg/FedBatchDesigner under the MIT license.
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Libiseller-Egger et al. (2025) studied this question.
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