Key result
The improved FK3V heart cell model, forced by a half-sine period stimulus, demonstrated both regular and irregular motion, with periodic and chaotic patterns detected.
The improved FK3V computational heart cell model effectively simulates both regular and chaotic transmembrane potential dynamics under varying stimulation parameters.
The main aim of this paper is to study the evolution of the transmembrane potential on the cardiac cell under different rates and amplitudes of stimulation. For modeling this potential, the modification of the Fenton‐Karma model was applied. It is a phenomenological model with 3 degrees of freedom that corresponds to nondimensional transmembrane potential and gating variables for regulation of inward and outward ion currents that can better reproduce the shape of the transmembrane potential than the original Fenton‐Karma model. The model was newly forced by stimulus with the shape of the half‐sine period. As the main goal of the paper is to show that this model is showing regular as well as irregular motion; periodic and chaotic patterns are detected using bifurcation diagrams, the Fourier spectra, Poincaré sections, and 0‐1 test for chaos.
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Halfar et al. (2018) studied Cardiac cell modeling. Improved FK3V heart cell model with half-sine period stimulus vs. Original Fenton-Karma model was evaluated on Evolution of the transmembrane potential under different rates and amplitudes of stimulation. The improved FK3V heart cell model, forced by a half-sine period stimulus, demonstrated both regular and irregular motion, with periodic and chaotic patterns detected.
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