Answers are grounded in this paper and cite their sources.
In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.
No takes yet. Share an insight, caveat, or question.
Mikhail V. Blagosklonny (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: