Key result
A 15-m depth scuba dive significantly increased plasma concentrations of BNP (18 to 21 ng/l, p=0.020), NT-proBNP (32 to 38 ng/l, p=0.008), and pro-BNP (7.8 to 10.3 ng/l, p=0.028) from baseline.
Why the study?
Does a 15-m depth scuba dive increase plasma concentrations of BNP precursor fragments in healthy scuba divers?
Observational (n=12)
Does a 15-m depth scuba dive increase plasma concentrations of BNP precursor fragments in healthy scuba divers?
Answers are grounded in this paper and cite their sources.
A 15-m depth scuba dive induces a slight but significant acute release of BNP precursor fragments, likely due to adrenergic activation and cardiac chamber dilation.
AIM: To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor. MATERIALS & METHODS: We studied 12 healthy scuba divers (mean age ± standard deviation: 44 ± 7 years; range: 34-55 years; BMI: 24.8 ± 2.8 kg/m(2)), who performed a 15-m depth dive in salt water, with a bottom time of 30 min. Blood samples for BNPs (pro-B-type natriuretic peptide [pro-BNP], BNP and aminoterminal pro-BNP) and catecholamines were measured in plasma before immersion, and after the dive. A continuous electrocardiographic recording was obtained during the entire protocol. RESULTS: BNP, aminoterminal pro-BNP and pro-BNP plasma concentrations slightly, but significantly, increased after the scuba dive (18 ± 15 to 21 ± 11 ng/l, p = 0.020; 32 ± 19 to 38 ± 21 ng/l, p = 0.008; and 7.8 ± 1.6 to 10.3 ± 3.6 ng/l, p = 0.028, respectively) in parallel with norepinephrine concentration (743 ± 323 to 1163 ± 656 ng/l, p = 0.014), with no variations in total plasma proteins, hematocrit or osmolality. A persistent sinus tachycardia was observed during all phases of the dive. CONCLUSIONS: A 15-m depth scuba dive induces an acute slight release of the different peptide fragments from the BNP precursor, likely through the stimulation of a constitutive secretory pathway promoted by adrenergic activation and cardiac chamber dilation.
No takes yet. Share an insight, caveat, or question.
Passino et al. (2011) conducted an observational in Healthy (n=12). 15-m depth scuba dive vs. Baseline (before immersion) was evaluated on Acute changes in plasma concentrations of BNP, aminoterminal pro-BNP, and pro-BNP (p=0.020). A 15-m depth scuba dive significantly increased plasma concentrations of BNP (18 to 21 ng/l, p=0.020), NT-proBNP (32 to 38 ng/l, p=0.008), and pro-BNP (7.8 to 10.3 ng/l, p=0.028) from baseline.
Synapse has enriched 10 related papers. Consider them for comparative context: