Cardiovascular system response to intravenous administration of physiologic sodium chloride solution in healthy subjects

V. A. Shurakova; А. Н. Куликов; I. Yu. Panina; A. Yu. Polushin; E. I. Lopatina; A. A. Tsynchenko; Elena Saganova; E. M. Timonina; A. G. Kamenchukov; D. E. Nagorny; T. A. Ulyankina; V. V. Dobrovolsky; A. M. Ginzburg

doi:10.24884/1682-6655-2025-24-1-64-72

April 9, 2025Regional blood circulation and microcirculationOpen Access

Cardiovascular system response to intravenous administration of physiologic sodium chloride solution in healthy subjects

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Key Points

To assess cardiovascular structure, function, and biomarker responses to high-volume intravenous sodium chloride solution in healthy adults.
Enrolled 5 healthy volunteers (mean age 31.6±5.3 years; 2 men, 3 women) who received intravenous 0.9% sodium chloride solution at 2.2 L/m² body surface area daily for approximately 10 hours per day over 2 days.
Measured body weight, blood pressure, heart rate, serum NT-proBNP levels, and transthoracic echocardiographic parameters at baseline, 48 hours, and 168 hours (7 days).
No significant changes were detected across the study period in blood pressure, heart rate, or body weight.
Serum NT-proBNP rose significantly from 29.3±17.67 ng/ml at baseline to 295.4±136.1 ng/ml at 48 hours (p=0.018) before normalizing to 38.0±20.94 ng/ml at 7 days (p=0.020).
Echocardiography at 48 hours revealed significant increases in left atrial volume (39.2±9.0 to 58.2±10.7 ml; p=0.003), right ventricular basal size (3.44±0.18 to 3.66±0.26 cm; p=0.020), right atrial vertical size (4.12±0.24 to 4.56±0.37 cm; p=0.032), TAPSE (2.5±0.27 to 2.94±0.25 cm; p=0.034), and the E/e' ratio (3.87±0.52 to 4.83±0.35; p=0.015).

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Implication

Interventional study reveals marked cardiac chamber enlargement and transient NT-proBNP spikes in healthy adults, suggesting fluid loading distorts cardiovascular diagnostic markers.

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Shurakova et al. (2025) studied this question.

synapsesocial.com/papers/6a81c5312ac899ae0206dd22 https://doi.org/10.24884/1682-6655-2025-24-1-64-72

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Cardiovascular system response to intravenous administration of physiologic sodium chloride solution in healthy subjects

Key Points

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Cardiovascular system response to intravenous administration of physiologic sodium chloride solution in healthy subjects

Key Points

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Implication

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Cite This Study

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