Why the study?
Are abnormalities of the glutathione system associated with the development of cardiometabolic abnormalities in apparently healthy obese women?
Are abnormalities of the glutathione system associated with the development of cardiometabolic abnormalities in apparently healthy obese women?
The study hypothesizes that glutathione parameters may help identify sub-clinical cardiometabolic abnormalities in obese women, though no results are provided in the abstract.
Hypothesis-generating only; leaves open whether glutathione parameters identify sub-clinical cardiometabolic abnormalities in obese women.
Objective: Oxidative stress plays a role in obesity-related diseases. We hypothesize that abnormalities of the glutathione system are associated with the initial phase leading to development of cardiometabolic abnormalities such as cardiovascular diseases and type 2 diabetes in apparently healthy obese women. By measuring different glutathione parameters, we expect to find a dichotomy that can discriminate between obese women who have such sub-clinical abnormalities.
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Lavoie et al. (2011) studied this question.
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