Key result
Multiple protein biomarkers are associated with early coronary heart disease, with the largest effect sizes seen for troponins (SMD 2.31; 95% CI 1.18-3.4) and MCP-1 (SMD 1.99; 95% CI 1.12-2.85).
Why the study?
Little information exists regarding the detection of early coronary heart disease protein biomarkers.
Are specific protein biomarkers associated with the early detection of coronary heart disease?
Meta-Analysis
Are specific protein biomarkers associated with the early detection of coronary heart disease?
Answers are grounded in this paper and cite their sources.
Multiple protein biomarkers, including troponins, IL-6, fibrinogen, and NT-proBNP, show significant differences and could potentially be used for early detection of coronary heart disease.
INTRODUCTION: Little information exists regarding the detection of early coronary heart disease protein biomarkers. The aim of this study was to investigate several potential candidates. METHODS: Systematic review was carried out followed by meta-analysis. RESULTS: The standardized mean difference (95% confidence intervals) for each comparison was: Troponins 2.31 (1.18, 3.4), iL-6 1.3 (0.8, 1.81), fibrinogen 1.55 (1.16, 1.94), NT-proBNP 1.05 (0.72, 1.38), lipoprotein a 0.75 (0.48, 1.03) osteoprotegerin 0.92 (0.23, 1.62), VCAM-1 1.53 (0.87, 2.18), pentraxin 3 0.87 (-0.13, 1.87), PAI-1 2.51 (-0.65, 5.66) MMP9 1.25 (0.36, 2.14), MCP-1 1.99 (1.12, 2.85) and adiponectin -1.11 (-1.49, -0.73). CONCLUSION: Multiple biomarkers that could potentially be used for the early detection of coronary heart disease were identified.
No takes yet. Share an insight, caveat, or question.
King et al. (2025) conducted a meta-analysis in Coronary artery disease. Protein biomarkers was evaluated on Early coronary heart disease (SMD 2.31, 95% CI 1.18-3.4). Multiple protein biomarkers are associated with early coronary heart disease, with the largest effect sizes seen for troponins (SMD 2.31; 95% CI 1.18-3.4) and MCP-1 (SMD 1.99; 95% CI 1.12-2.85).
Synapse has enriched 10 related papers. Consider them for comparative context: