Acute Asthma Attack Due to Ophthalmic Indomethacin

Brief Reports15 August 1989Acute Asthma Attack Due to Ophthalmic IndomethacinGerard J. Sheehan, MB, Morley R Kutzner, MD, Wu D. Chin, MBGerard J. Sheehan, MBSearch for more papers by this author, Morley R Kutzner, MDSearch for more papers by this author, Wu D. Chin, MBSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-4-337 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOphthalmic timolol has recently been recognized as a cause of exacerbation of asthma. Recently we encountered another ophthalmic solution, indomethacin, that caused a life-threatening episode in an asthmatic patient.Case ReportA 79-year-old woman had a long history of adult-on-set asthma treated by inhaled salbutamol and beclomethasone. Two years before, she had a myocardial infarction and subsequently received regular furosemide for cardiac failure. She had chronic hypertension for which she received nifedipine. In 1980, she had bilateral cataract extractions. Because of difficulty tolerating contact lenses, in 1987 a lens was surgically implanted. After surgery, she was treated with topical tapering...References1. VanselowSmith NJ. Bronchial asthma induced by indomethacin. Ann Intern Med. 1967;66:568-72. LinkGoogle Scholar2. Smith A. Responsiveness of aspirin-allergic patients to challenge by some analgesics in common use. Br Med J 1971;2:494-6. CrossrefMedlineGoogle Scholar3. BotetGrauBenitoCollVivancos CJPJJ. Timolol ophthalmic solution and respiratory arrest [Letter]. Ann Intern Med. 1986;105:306-7. LinkGoogle Scholar4. PrinceCarliner DN. Respiratory arrest following first dose of timolol ophthalmic solution. Chest. 1983;84:640-1. CrossrefMedlineGoogle Scholar5. Timperman J. A fatal asthmatic attack following administration of an indomethacin suppository. J Forensic Med. 1971;18:30-2. MedlineGoogle Scholar6. SantiagoKlaustermeyer SW. Acute respiratory failure secondary to indomethacin in an aspirin-intolerant asthmatic patient. Ann Allergy. 1976;37:138-41. MedlineGoogle Scholar7. Waitzman M. Topical indomethacin in treatment and prevention of intraocular inflammation. Ann Ophthalmol. 1979;11:489-91. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of Alberta Hospitals, the University of Alberta, and Royal Alexandra Hospital; Edmonton, Alberta, Canada. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAnalgesics, Narcotic Antagonists, and Drugs Used to Treat ArthritisCataract surgery and nonsteroidal antiinflammatory drugsIndometacinManagement of pseudophakic cystoid macular edemaDrug-induced ocular side effectsNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)Drug-induced ocular side effectsTopical Non-Steroidal Anti-Inflammatory Drugs in Allergic Conjunctivitis: Meta-Analysis of Randomized Trial DataTopical Bromfenac Sodium for Long-Term Management of Vernal KeratoconjunctivitisThe Role of NSAIDs in the Management of Postoperative Ophthalmic InflammationToxic Keratolysis from Combined use of Nonsteroid Anti-Inflammatory Drugs and Topical Steroids following Vitreoretinal SurgeryIndometacinSystemic adverse effects of topical ocular treatmentsNonsteroidal anti-inflammatory drugs in veterinary ophthalmologyPossibility of non-steroidal treatment in allergic conjunctival diseasesThe mechanisms of aspirin-intolerant asthma and its managementTopical Nonsteroidal Anti-Inflammatory Drugs for Ophthalmic UseOral and inhalation provocation tests for the diagnosis of aspirin-induced asthmaKeratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugsDrugs used in ocular treatmentDIAGNOSIS AND TREATMENT OF ASTHMA IN THE ELDERLYPharmacotherapy of photorefractive keratectomyAsthma Caused by Topical Application of KetorolacRESPIRATORY FAILURE AS A RESULT OF DRUGS, OVERDOSES, AND POISONINGSA diagnostic approach to ‘difficult’ asthmaEye Surgery in the ElderlyPulmonary Complications From Ophthalmic PreparationsDrug-Induced BronchospasmAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 15 August 1989Volume 111, Issue 4Page: 337-338KeywordsAsthmaHeart failureHypertensionMyocardial infarctionSurgery Issue Published: 15 August 1989 PDF DownloadLoading ...