What question did this study set out to answer?

To evaluate the independent predictive value of adding multigene profiling to standard immunohistochemical profiling for pathological complete response and axillary lymph node conversion after neoadjuvant chemotherapy.

May 31, 2023npj Breast CancerOpen Access

Multigene profiles to guide the use of neoadjuvant chemotherapy for breast cancer: a Copenhagen Breast Cancer Genomics Study

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Authors

MJMaj‐Britt JensenCopenhagen University Hospital CPChristina B. PedersenUniversity of Southern Denmark MMMaria-Anna MisiakouNovo Nordisk Foundation

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Implication

Cohort study reveals multigene profiling independently predicts neoadjuvant chemotherapy response in breast cancer, indicating improved treatment selection for estrogen receptor-positive disease.

Key Points

To evaluate the independent predictive value of adding multigene profiling to standard immunohistochemical profiling for pathological complete response and axillary lymph node conversion after neoadjuvant chemotherapy.
Evaluated a cohort of 458 breast cancer patients who underwent standard-of-care genomic profiling.
Used logistic regression models to assess the predictive capacity of CIT256 and PAM50 multigene expression profiles alongside standard immunohistochemical profiles.
Patients with Non-luminal multigene subtypes showed significantly higher pathological complete response and lymph node conversion rates, with predictive value independent of immunohistochemical profile.
In the ER-positive and HER2-negative subgroup, CIT256 Non-luminal subtypes had higher pathological complete response than Luminal subtypes (OR 9.78, 95% CI 2.60 to 36.8, P < 0.001).

Cite This Study

Jensen et al. (2023) studied this question.

synapsesocial.com/papers/6a81e33428bb6950eb610a45 https://doi.org/10.1038/s41523-023-00551-0

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Implication

Cohort study reveals multigene profiling independently predicts neoadjuvant chemotherapy response in breast cancer, indicating improved treatment selection for estrogen receptor-positive disease.

Multigene profiles to guide the use of neoadjuvant chemotherapy for breast cancer: a Copenhagen Breast Cancer Genomics Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Multigene profiles to guide the use of neoadjuvant chemotherapy for breast cancer: a Copenhagen Breast Cancer Genomics Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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