Why the study?
Rectal angiosarcoma is an exceptionally rare and aggressive malignancy with diagnostic and therapeutic challenges and a lack of established guidelines.
This case report highlights the successful use of a multidisciplinary approach, including IMRT/VMAT radiation and surgery, for treating rare stage IIIB rectal angiosarcoma.
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Supports multidisciplinary therapy in rare rectal angiosarcoma; hypothesis-generating and requires prospective validation before practice change.
Background and Clinical Significance: Rectal angiosarcoma is an exceptionally rare and aggressive malignancy, comprising less than 1% of soft tissue sarcomas. This case highlights the diagnostic and therapeutic challenges posed by this disease, and the lack of established guidelines emphasizing the importance of a multidisciplinary approach. Case Presentation: A 41-year-old male firefighter, with a history of heavy smoking, presented with lower abdominal pain, rectal bleeding, and urgency. Imaging and biopsy confirmed rectal angiosarcoma, stage IIIB. The patient underwent IMRT/VMAT radiation therapy followed by laparoscopic rectal amputation with colostomy. No sign of recurrence or metastatic disease was present on follow-up imaging. Conclusions: This case underlines the importance of a personalized treatment strategy and multidisciplinary collaboration in rare malignancies. Early diagnosis and cooperation across specialties are critical for achieving the best possible outcomes.
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Jinga et al. (2025) studied this question.
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