Vagal denervation of the HCl glands by transforming Pavlov pouches into Heidenhain pouches markedly reduced the submaximal acid secretory response to exogenous gastrin in four fasting dogs but reduced the submaximal acid secretory response to histamine in only one of four dogs, three dogs being common to the gastrin and histamine studies. The results suggest that a continuous vagal discharge on the HCl glands is necessary to maintain the sensitivity of the glands to gastrin. An interpretation is presented for the different effects of vagal denervation on the sensitivity of the HCl glands to gastrin and histamine.
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Andersson et al. (1964) studied this question.
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