A domino hydroboration/trifluoromethylation (formal hydrotrifluoromethylation) of alkynes using the fluoroform-derived [CuCF 3 ] reagent is achieved. Synthetically useful ( E )-alkenyl-CF 3 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient conditions in one pot/one step from alkynes. The ultimate source of CF 3 is the inexpensive industrial waste fluoroform.
No takes yet. Share an insight, caveat, or question.
He et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: